Parathyroid Hormone Deficiency and Excess: Similar Effects on Trabecular Bone But Differing Effects on Cortical Bone
نویسندگان
چکیده
منابع مشابه
Effects of parathyroid hormone dosage and schedule on bone regeneration.
This study investigated the effects of administration of parathyroid hormone (PTH) at different dosages and schedules on bone regeneration in critical-size bone defects in rat calvariae. After calvarial defects had been prepared in 50 rats, they were divided into five treatment groups: 15 µg/kg PTH daily (PTH-15), 35 µg/kg PTH three times per week (PTH-35), 105 µg/kg once per week (PTH-105-1), ...
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Intermittent PTH treatment increases cancellous bone mass in osteoporosis patients; however, it reveals diverse effects on cortical bone mass. Underlying molecular mechanisms for anabolic PTH actions are largely unknown. Because PTH regulates expression of osteopontin (OPN) in osteoblasts, OPN could be one of the targets of PTH in bone. Therefore, we examined the role of OPN in the PTH actions ...
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Growth hormone (GH) has profound effects on linear bone growth, bone metabolism and bone mass. The GH receptor is found on the cell surface of osteoblasts and osteoclasts, but not on mature osteocytes. In vitro, GH stimulates proliferation, differentiation and extracellular matrix production in osteoblast-like cell lines. GH also stimulates recruitment and bone resorption activity in osteoclast...
متن کاملCortical and Trabecular Bone
During the normal growth and development of man and animals the bones grow in length and width and undergo progressive changes in their architecture, a process known as maturation. These normal processes are governed by numerous and complex forces but one of them, the plane of nutrition during the growing period, is of major importance. Undernourished children are small in stature and have bone...
متن کاملRAGE supports parathyroid hormone-induced gains in femoral trabecular bone.
Parathyroid hormone (PTH) restores bone mass to the osteopenic skeleton, but significant questions remain as to the underlying mechanisms. The receptor for advanced glycation end products (RAGE) is a multiligand receptor of the immunoglobulin superfamily; however, recent studies indicate a role in bone physiology. We investigated the significance of RAGE to hormone-induced increases in bone by ...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 1999
ISSN: 0021-972X
DOI: 10.1210/jc.84.2.718